HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → HCID 53848828, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Dimethyl N-cyanodithioiminocarbonate | HCID 66289 | — |
| Reactant | 2-{[(3-Bromopyridin-2-yl)methyl]sulfanyl}ethan-1-amine | HCID 12951527 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 53848828 | HCID 53848828 | — |
Reaction Steps
Sequential reaction of dimethylcyanodithioimidocarbonate with 2-((2-aminoethyl)thiomethyl)-3-bromopyridine) and excess methylamine at room temperature in ethanol, the methylamine being added after initial standing overnight and the solution then allowed to stand for a further four hours, followed by chromatographic purification on a column of silica gel with elution by ethyl acetate and final recrystallisation from ethyl acetate-petroleum ether gave N-cyano-N'-[2-((3-bromo-2-pyridyl)methylthio)ethyl]-N"-methylguanidine m.p. 114°-116°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04000302 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-aa72ff1005a94025a06584965be363c9 |
| Source note | uspto-grants-1976_12 |