反应详情

The compound 17β-hydroxy-7α-methylestr-4-en-3-one acetate, prepared in accordance with the preceding Example, is dissolved in 400 ml of methanol containing 9.5 g of sodium methoxide. The yellow solution is stirred for 2 hours at room temperature under nitrogen and poured onto an ice-water mixture. The solid which forms is filtered and recrystallized from an acetone-hexane mixture to yield 11.3 g (two crops) of 17β-hydroxy-7α-methylestr-4-en-3-one having a melting point of 144°-6° C.

1. filtrationThe solid which forms is filtered
2. customrecrystallized from an acetone-hexane mixture