Trestolone → HCID 22795290, compound

HRID 1974429Notes

Reaction equation

HRID 1974429 reaction equation
C(O)(=O)C.O[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@]12C)[C@@H]1C(=CC(=O)CC1)C[C@H]3C.[CH3:26][C@@H:27]1[CH2:44][C:43]2[C@H:38]([CH2:39][CH2:40][C:41](=[O:45])[CH:42]=2)[C@@H:37]2[C@@H:28]1[C@H:29]1[C@@:33]([CH2:35][CH2:36]2)([CH3:34])[C@@H:32]([O:46][Si:47]([CH3:50])([CH3:49])[CH3:48])[CH2:31][CH2:30]1.[CH3:51][O:52][C:53]1([O:59][C@H:60]2[CH2:65][CH2:64][C@H:63]3[C@H:66]4[C@H:75]([CH2:76][CH2:77][C@:61]23[CH3:62])[C@@H:74]2[C:69](=[CH:70][C:71](=[O:78])[CH2:72][CH2:73]2)[CH2:68][C@H:67]4[CH3:79])[CH2:58][CH2:57][CH2:56][CH2:55][CH2:54]1.O[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@]12C)[C@@H]1C(=CC(=O)CC1)C[C@H]3C>>[C:53]([O:59][C@H:60]1[CH2:65][CH2:64][C@H:63]2[C@H:66]3[C@H:75]([CH2:76][CH2:77][C@:61]12[CH3:62])[C@@H:74]1[C:69](=[CH:70][C@H:71]([OH:78])[CH2:72][CH2:73]1)[CH2:68][C@H:67]3[CH3:79])(=[O:52])[CH3:54].[CH3:26][C@@H:27]1[CH2:44][C:43]2[C@H:38]([CH2:39][CH2:40][C@@H:41]([OH:45])[CH:42]=2)[C@@H:37]2[C@@H:28]1[C@H:29]1[C@@:33]([CH2:35][CH2:36]2)([CH3:34])[C@@H:32]([O:46][Si:47]([CH3:49])([CH3:48])[CH3:50])[CH2:31][CH2:30]1.[CH3:51][O:52][C:53]1([O:59][C@H:60]2[CH2:65][CH2:64][C@H:63]3[C@H:66]4[C@H:75]([CH2:76][CH2:77][C@:61]23[CH3:62])[C@@H:74]2[C:69](=[CH:70][C@H:71]([OH:78])[CH2:72][CH2:73]2)[CH2:68][C@H:67]4[CH3:79])[CH2:58][CH2:57][CH2:56][CH2:55][CH2:54]1

Participants

7

Reactant 4

HCID 9838899TrestoloneHCID 22795301HCID 22795301, compoundHCID 22795303HCID 22795303, compoundHCID 86734345HCID 86734345, compound

Product 3

HCID 22795290HCID 22795290, compoundHCID 22795302HCID 22795302, compoundHCID 68131708HCID 68131708, compound

Procedure

Following essentially the same procedure but substituting the compounds 17β-hydroxy-7α-methylestr-4-en-3-one acetate, 7α-methyl-17β-trimethylsiloxy-estr-4-en-3-one and 17β-(1'-methoxycyclohexyloxy)-7α-methylestr-4-en-3-one for the 17β-hydroxy-7α-methylestr-4-en-3-one above, results in the formation of 7α-methylestr-4-ene-3α,17β-diol 17-acetate, 7α-methyl-17β-trimethylsiloxy-estr-4-en-3α-ol and 17β-(1'-methoxycyclohexyloxy)-7α-methylestr-4-en-3α-ol, respectively.

Sources & evidence

ORD record
ord-d3fd02dc7cdd4dc195b37421eb71e22b
Source dataset
uspto-grants-1976_12
Patent number
US04000273

Reaction notes

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