Potassium Hydroxide → HCID 19383088, compound

Participants

Reaction Steps

A mixture of methyl 2-[4-[(2-propyl-1H-benzimidazol-1-yl)methyl]phenyl]-1-cyclopentene-1-carboxylate (1.60 g, 4.27 mmol), 1N KOH (8.5 mL), and dioxane (8.5 mL) was heated under reflux for 1 h. The mixture was concentrated, diluted with water (10 mL), and extracted with ether (discarded). The aqueous phase was neutralized with 1N HCl (8.5 mL) and the white precipitate was collected by filtration. Trituration with EtOH gave 1.04 g (68%) of product, mp 224°-226° C.

Provenance & Evidence