HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 6-(1H-Imidazol-2-yl)-3-nitro-2-pyridinamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 6-Chloro-3-nitropyridin-2-ylamine | HCID 2724035 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-(1H-Imidazol-2-yl)-3-nitro-2-pyridinamine | HCID 19101570 | 79.5% |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
In 80 ml of N,N-dimethylformamide were dissolved 4.00 g of 2-amino-6-chloro-3-nitropyridine and 15.69 g of imidazole, and the solution was stirred at 120° C. overnight. After spontaneous cooling to room temperature, 100 ml of water was added and the resulting crystals were collected by filtration. The crystals were rinsed with a small amount of water and dried under reduced pressure to provide 3.76 g of 2-amino-6-imidazolyl-3-nitropyridine. Physicochemical properties:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05283244 |
| Source dataset | uspto-grants-1994_02 |
| ORD ID | ord-8083c1e4eb534a719866e28c0fed96f7 |
| Source note | uspto-grants-1994_02 |