HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 4-Amino-2-(1-imidazolyl)-5-nitrobenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | 4-Amino-2-fluoro-5-nitrobenzonitrile | HCID 10419793 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Amino-2-(1-imidazolyl)-5-nitrobenzonitrile | HCID 10443784 | 94.8% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
In 5 ml of DMF were dissolved 1 g of 4-amino-2-fluoro-5-nitrobenzonitrile and 1.1 g of imidazole, and the mixture was stirred at 100° C. for 1 hour. The reaction mixture was then diluted with water and the resulting crystals were recovered by filtration to provide 1.2 g of 4-amino-2-(1-imidazolyl)-5-nitrobenzonitrile. Physicochemical properties:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05283244 |
| Source dataset | uspto-grants-1994_02 |
| ORD ID | ord-e22b3da583c34e09ab26d9a16d00bdb4 |
| Source note | uspto-grants-1994_02 |