Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Benzimidazole | HCID 5798 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 6-Fluoro-7-nitro-1,4-dihydroquinoxaline-2,3-dione | HCID 9991230 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 9973454 | HCID 9973454 | 12.2% |
Reaction Steps
A dry DMSO solution containing 1.2 g of 6-fluoro-7-nitroquinoxaline-2,3-(1H,4H)-dione, 740 mg of potassium hydroxide powder and 1.3 g of benzimidazole was stirred with heating at 130° C. for 5.5 hours. The reaction mixture was then poured in ice-water, followed by addition of hydrochloric acid, and the mixture was filtered at pH about 9 to separate insolubles. The filtrate was then adjusted to pH about 7 with hydrochloric acid, whereupon crystals separated out again. These crystals were collected by filtration to provide 210 mg of 6-(benzimidazol-1-yl)-7-nitroquinoxaline-2,3-(1H,4H)-dione.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05283244 |
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| Source dataset | uspto-grants-1994_02 |
|---|
| ORD ID | ord-5dfaf9000b9147e7952ec7b2c71d6797 |
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| Source note | uspto-grants-1994_02 |
|---|
