Sodium Hydroxide → HCID 19101574, compound

HRID 1974483Notes

Reaction equation

HRID 1974483 reaction equation
Cl.[NH:2]1[CH:6]=[CH:5][N:4]=[C:3]1[C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[NH:13][C:12](=[O:17])[C:11](=[O:18])[NH:10]2.[N+:19]([O-])([O-:21])=[O:20].[K+].[OH-].[Na+]>S(=O)(=O)(O)O>[NH:2]1[CH:6]=[CH:5][N:4]=[C:3]1[C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][C:16]=1[N+:19]([O-:21])=[O:20])[NH:13][C:12](=[O:17])[C:11](=[O:18])[NH:10]2

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 24434Potassium NitrateHCID 19101606HCID 19101606, compound

Product 1

HCID 19101574HCID 19101574, compoundYield 52.3%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Conditions

Temperature
70 °C

Procedure

In 5 ml of sulfuric acid was dissolved 0.5 g of 6-imidazolylquinoxaline-2,3-(1H,4H)-dione hydrochloride followed by addition of 0.21 g of potassium nitrate, and the resulting mixture was heated at 70° C. for 5 minutes. After spontaneous cooling to room temperature, the reaction mixture was poured in ice-water and adjusted to pH 4-5 with aqueous sodium hydroxide solution, whereupon crystals separated out. These crystals were recovered by filtration and recrystallized from DMF-water to provide 0.27 g of 6-imidazolyl-7-nitroquinoxaline-2,3-(1H,4H)-dione.

Workup

  1. temperatureAfter spontaneous cooling to room temperature
  2. customseparated out
  3. filtrationThese crystals were recovered by filtration
  4. customrecrystallized from DMF-water

Sources & evidence

ORD record
ord-be4375da04dc4d8896a08fe8ee10ba3f
Source dataset
uspto-grants-1994_02
Patent number
US05283244

Reaction notes

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