Sodium Hydroxide → HCID 19101616, compound

HRID 1974485Notes

Reaction equation

HRID 1974485 reaction equation
O.[N:2]1([C:7]2[CH:16]=[C:15]([N:17]3[CH:21]=[CH:20][N:19]=[CH:18]3)[CH:14]=[C:13]3[C:8]=2[NH:9][C:10](=[O:23])[C:11](=[O:22])[NH:12]3)[CH:6]=[CH:5][N:4]=[CH:3]1.[N+:24]([O-])([O-:26])=[O:25].[K+].[OH-].[Na+]>S(=O)(=O)(O)O>[N:2]1([C:7]2[C:16]([N+:24]([O-:26])=[O:25])=[C:15]([N:17]3[CH:21]=[CH:20][N:19]=[CH:18]3)[CH:14]=[C:13]3[C:8]=2[NH:9][C:10](=[O:23])[C:11](=[O:22])[NH:12]3)[CH:6]=[CH:5][N:4]=[CH:3]1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 24434Potassium NitrateHCID 19101625HCID 19101625, compound

Product 1

HCID 19101616HCID 19101616, compoundYield 39.4%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

In 3 ml of concentrated sulfuric acid was dissolved 290 mg of 5,7-di-(1-imidazolyl)quinoxaline-2,3-(1H,4H)-dione hydrate followed by addition of 220 mg of potassium nitrate with ice-cooling. After cooling to room temperature, the reaction mixture was further stirred at 80° C. for 30 minutes. After cooling to room temperature, the reaction mixture was poured in ice-water and adjusted to pH 7 with sodium hydroxide. The resulting crystals were recovered by filtration and washed with water to provide 124 mg of 5,7-di(1-imidazolyl)-6-nitroquinoxaline-2,3-(1H,4H)-dione.

Workup

  1. temperaturecooling
  2. temperatureAfter cooling to room temperature
  3. filtrationThe resulting crystals were recovered by filtration
  4. washwashed with water

Sources & evidence

ORD record
ord-7397994e29404768a0ce9662fbcd979e
Source dataset
uspto-grants-1994_02
Patent number
US05283244

Reaction notes

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