2-Amino-3-methylpyridine → SRC-820 R

HRID 1974491Notes

Reaction equation

HRID 1974491 reaction equation
[CH3:1][C:2]1[O:12][C:10](=O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH2:13][C:14]1[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][N:15]=1>>[CH3:1][C:2]1[N:13]([C:14]2[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][N:15]=2)[C:10](=[O:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 153472-Amino-3-methylpyridineHCID 68236Acetanthranil

Product 1

HCID 63120SRC-820 R

Procedure

Acetanthranil (4.5 g, 0.028 mole) was mixed with 2-amino-3-picoline (2.7 g, 0.025 mole) and the mixture was heated in an erlenmeyer flask, first at low heat and then at high heat over an open flame. The product was washed with ether and recrystallized from ethanol/water mixture. The yield was 3.7 g (58%), mp 135°-137° C.

Workup

  1. temperaturethe mixture was heated in an erlenmeyer flask
  2. temperaturefirst at low heat
  3. temperatureat high heat over an open flame
  4. washThe product was washed with ether
  5. customrecrystallized from ethanol/water mixture

Sources & evidence

ORD record
ord-219d2a8943c040f0884dba93c668e765
Source dataset
uspto-grants-1994_02
Patent number
US05283247

Reaction notes

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