HCID 10092922, compound → HCID 172939001, compound

HRID 1974498Notes

Reaction equation

HRID 1974498 reaction equation
[C:1]1(/[C:7](=[N:22]\[O:23][CH2:24][CH2:25][CH2:26][CH2:27][C:28]([OH:30])=[O:29])/[CH:8]([N:17]2[CH:21]=[CH:20][N:19]=[CH:18]2)[CH2:9][C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C[O-].[Na+:33]>CO>[C:1]1(/[C:7](=[N:22]\[O:23][CH2:24][CH2:25][CH2:26][CH2:27][C:28]([O-:30])=[O:29])/[CH:8]([N:17]2[CH:21]=[CH:20][N:19]=[CH:18]2)[CH2:9][C:10]2[CH:11]=[CH:12][C:13]([F:16])=[CH:14][CH:15]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Na+:33]

Participants

4

Reactant 2

HCID 10092922HCID 10092922, compoundHCID 10942334Sodium Methoxide

Product 1

HCID 172939001HCID 172939001, compoundYield 449.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a stirred solution of 1 g (0.0005 moles) of (±) (E)-5-[1-phenyl-2-(imidazol-1-yl)-2-(4-fluorobenzyl)ethylidene] aminoxypentanoic acid in 10 ml of methanol, 820 mg (0.015 moles) of a sodium methoxide solution in methanol are added. The reaction mixture is evaporated and the precipitate product is filtered off and dried yielding 970 mg (60%) of sodium (±)(E)-5-[1-phenyl-2-(imidazol-1-yl)-2-(4-fluorobenzyl)ethylidene]aminoxypentanoate.

Workup

  1. customThe reaction mixture is evaporated
  2. filtrationthe precipitate product is filtered off
  3. customdried

Sources & evidence

ORD record
ord-713ab2b794e348d8b05c08c4a6422b5f
Source dataset
uspto-grants-1994_02
Patent number
US05283254

Reaction notes

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