HCID 19101639, compound → HCID 19101641, compound

HRID 1974510Notes

Reaction equation

HRID 1974510 reaction equation
Br.[N:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]#[C:9][CH2:10]Br.[F:12][C:13]1[CH:14]=[C:15]([OH:29])[CH:16]=[C:17]([C:19]([C:24]2[S:25][CH:26]=[CH:27][N:28]=2)([O:22][CH3:23])[CH2:20][CH3:21])[CH:18]=1>>[F:12][C:13]1[CH:14]=[C:15]([O:29][CH2:10][C:9]#[C:8][C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][N:2]=2)[CH:16]=[C:17]([C:19]([C:24]2[S:25][CH:26]=[CH:27][N:28]=2)([O:22][CH3:23])[CH2:20][CH3:21])[CH:18]=1

Participants

3

Reactant 2

HCID 19101639HCID 19101639, compoundHCID 19387898HCID 19387898, compound

Product 1

HCID 19101641HCID 19101641, compoundYield 54%

Procedure

Using a similar procedure to that described in Example 8, 3-(2-pyridyl)prop-2-yn-1-yl bromide hydrobromide was reacted with 2-[1-(5-fluoro-3-hydroxyphenyl)-1-methoxypropyl]thiazole to give 2-[1-[5-fluoro-3-(3-(2-pyridyl)prop-2-yn-1-yloxy)phenyl]-1-methoxypropyl]thiazole in 54% yield, as an oil.

Sources & evidence

ORD record
ord-0dd2f6c511e946dda0329ea313f14c59
Source dataset
uspto-grants-1994_02
Patent number
US05283245

Reaction notes

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