HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Bromomethyl)quinoline → 2-[1-Methoxy-1-[3-methoxy-4-(quinol-2-ylmethoxy)phenyl]propyl]thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Bromomethyl)quinoline | HCID 12417418 | — |
| Reactant | 2-[1-(4-Hydroxy-3-methoxyphenyl)-1-methoxypropyl]thiazole | HCID 19101629 | — |
| Product | 2-[1-Methoxy-1-[3-methoxy-4-(quinol-2-ylmethoxy)phenyl]propyl]thiazole | HCID 19101657 | 52% |
Reaction Steps
Using a similar procedure to that described in Example 1, 2-bromomethylquinoline was reacted with 2-[1-(4-hydroxy-3-methoxyphenyl)-1-methoxypropyl]thiazole to give 2-[1-methoxy-1-[3-methoxy-4-(quinol-2-ylmethoxy)phenyl]propyl]thiazole in 52% yield, m.p. 100°-102° C. (recrystallised from a mixture of petroleum ether (b.p. 60°-80° C.) and methylene chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05283245 |
| Source dataset | uspto-grants-1994_02 |
| ORD ID | ord-3af671f693404793a79a308bf5beb0dc |
| Source note | uspto-grants-1994_02 |