3-(Bromomethyl)quinolin-2(1H)-one → 2-[1-Methoxy-1-[3-methoxy-4-(1,2-dihydro-2-oxoquinolin-3-ylmethoxy)phenyl]propyl]thiazole

Participants

Reaction Steps

Using a similar procedure to that described in Example 1, 3-bromomethyl-1,2-dihydroquinolin-2-one was reacted with 2-[1-(4-hydroxy-3-methoxyphenyl)-1-methoxypropyl]thiazole to give 2-[1-methoxy-1-[3-methoxy-4-(1,2-dihydro-2-oxoquinolin-3-ylmethoxy)phenyl]propyl]thiazole in 28% yield, m.p. 170°-171° C. (recrystallised from a mixture of hexane and ethyl acetate).

Provenance & Evidence