Methanesulfonyl chloride → 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[-3-[(methylsulfonyl)amino]-1-oxopropyl]hydrazide

HRID 1974517Notes

Reaction equation

HRID 1974517 reaction equation
Cl.[NH2:2][CH2:3][CH2:4][C:5]([NH:7][NH:8][C:9]([N:11]1[CH2:17][C:16]2[CH:18]=[CH:19][CH:20]=[CH:21][C:15]=2[O:14][C:13]2[CH:22]=[CH:23][C:24]([Cl:26])=[CH:25][C:12]1=2)=[O:10])=[O:6].[CH3:27][S:28](Cl)(=[O:30])=[O:29]>>[CH3:27][S:28]([NH:2][CH2:3][CH2:4][C:5]([NH:7][NH:8][C:9]([N:11]1[CH2:17][C:16]2[CH:18]=[CH:19][CH:20]=[CH:21][C:15]=2[O:14][C:13]2[CH:22]=[CH:23][C:24]([Cl:26])=[CH:25][C:12]1=2)=[O:10])=[O:6])(=[O:30])=[O:29]

Participants

3

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 1317177198-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(3-amino-1-oxopropyl)hydrazide, monohydrochloride

Product 1

HCID 152373998-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[-3-[(methylsulfonyl)amino]-1-oxopropyl]hydrazide

Procedure

8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[-3-[(methylsulfonyl)amino]-1-oxopropyl]hydrazide (11) was prepared from 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(3-amino-1-oxopropyl)hydrazide, monohydrochloride (9), prepared as described above in Example 9, and methanesulfonyl chloride, in the manner described in Example 10 above on a 2-mmol scale to yield 0.46 g (52%) of product. Analysis calculated for C18H19N4O5ClS (M.W. 438.88): C, 49.26; H, 4.36; N, 12.77. Found: C, 49.05; H, 4.40; N, 12.66.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-30820bf1416a40a7bebb79447c19dd30
Source dataset
uspto-grants-1994_02
Patent number
US05283240

Reaction notes

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