2-Oxopropanoyl chloride → Pyruvyl-alanine trimethylsilyl ester

Participants

Reaction Steps

A method of synthesizing pyruvyl-alanine or pyruvyl-glycine according to the invention comprises the steps of reacting sodium pyruvate with oxalyl chloride to yield pyruvylchloride, then reacting pyruvylchloride with a suspension of alanine trimethylsilyl ester hydrochloride to yield a pyruvyl-alanine trimethylsilyl ester and then subjecting the pyruvyl-alanine trimethylsilyl esterto hydrolysis toyieldpyruvyl-alanine. The pyruvyl-alanine synthesized via the method set forth above serves as a pyruvyl-amino acid pyruvate precursor.

Provenance & Evidence