2-Oxopropanoyl chloride → HCID 86747338, compound

HRID 1974549Notes

Reaction equation

HRID 1974549 reaction equation
[C:1](Cl)(=[O:5])[C:2]([CH3:4])=[O:3].Cl.[CH3:8][Si:9]([O:12][C:13](=[O:20])[C@H:14]([C@H:16]([CH2:18][CH3:19])[CH3:17])[NH2:15])([CH3:11])[CH3:10]>>[CH3:11][Si:9]([O:12][C:13](=[O:20])[C@H:14]([C@H:16]([CH2:18][CH3:19])[CH3:17])[NH:15][C:1](=[O:5])[C:2]([CH3:4])=[O:3])([CH3:8])[CH3:10]

Participants

3

Reactant 2

HCID 5217912-Oxopropanoyl chlorideHCID 86747339HCID 86747339, compound

Product 1

HCID 86747338HCID 86747338, compound

Procedure

A method of synthesizing pyruvyl-isoleucine according to the invention the steps of reacting sodium pyruvate with oxalyl chloride to yield pyruvyl chloride, then reacting the pyruvyl chloride with a suspension of isoleucine trimethylsilyl ester hydrochloride to yield pyruvyl-isoleucine trimethylsilyl ester and then subjecting the pyruvyl-isoleucine trimethylsilyl ester to hydrolysis to yield pyruvyl-isoleucine. The pyruvyl-isoleucine synthesized via the method set forth above serves as a pyruvyl-amino acid pyruvate precursor.

Sources & evidence

ORD record
ord-f51310a7aa4e4ebeab7c42d265df747b
Source dataset
uspto-grants-1994_02
Patent number
US05283260

Reaction notes

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