Hydrochloric Acid → HCID 19101731, compound

Participants

Reaction Steps

To a solution of benzyl 4-[1-(3-nitrobenzenesulfonyl)indol-3-yl]butyrate (1.95 g) in 1,4-dioxane (15 ml) was added 1N-sodium hydroxide (8 ml). The mixture was stirred for 2 hours and poured into diluted hydrochloric acid. The organic layer was extracted with ethyl acetate (30 ml) and washed with water (30 ml×3). The solution was dried over magnesium sulfate and the solvent was removed in vacuo. The residue was crystallized with diisopropyl ether to give a yellow solid of 4-[1-[3-nitrobenzenesulfonyl)indol-3-yl]butyric acid (1.45 g).

Provenance & Evidence