Boron tribromide dichloromethane → HCID 54439514, 화합물

HRID 1974704노트

반응식

HRID 1974704 반응식
C[O:2][C:3]1[CH:4]=[C:5]([CH:12]=[CH:13][CH:14]=[CH:15][C:16]([OH:18])=[O:17])[C:6]([Cl:11])=[CH:7][C:8]=1[O:9]C.B(Br)(Br)Br.ClCCl>ClCCl>[OH:2][C:3]1[CH:4]=[C:5]([CH:12]=[CH:13][CH:14]=[CH:15][C:16]([OH:18])=[O:17])[C:6]([Cl:11])=[CH:7][C:8]=1[OH:9]

참가 물질

4

반응물 2

HCID 22277759Boron tribromide dichloromethaneHCID 540567045-(3,4-Dimethoxy-6-chlorophenyl)-2,4-pentadienoic acid

생성물 1

HCID 54439514HCID 54439514, 화합물수율 46%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
20 °C

실험 절차

To a solution containing 0.54 g of the product obtained in Example 35 in 6 ml dichloromethane 6 ml of 1 molar boron tribromide-dichloromethane solution was added and stirred for 24 h at 20° C. The solvent was evaporated in vacuo and 2N hydrochloric acid was added to the residue. The product was filtered and washed with water. Recrystallization from isopropanol-water yielded 0.22 g (46%) of the product desired, m.p. 203°-206° C.

후처리

  1. additionwas added
  2. customThe solvent was evaporated in vacuo and 2N hydrochloric acid
  3. additionwas added to the residue
  4. filtrationThe product was filtered
  5. washwashed with water
  6. customRecrystallization from isopropanol-water

출처 및 근거

ORD 기록
ord-be3715303671428a9e7437592a5e337b
출처 데이터셋
uspto-grants-1994_02
특허 번호
US05283352

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