反应详情

温度

20 °C

To a solution containing 0.54 g of the product obtained in Example 35 in 6 ml dichloromethane 6 ml of 1 molar boron tribromide-dichloromethane solution was added and stirred for 24 h at 20° C. The solvent was evaporated in vacuo and 2N hydrochloric acid was added to the residue. The product was filtered and washed with water. Recrystallization from isopropanol-water yielded 0.22 g (46%) of the product desired, m.p. 203°-206° C.

1. additionwas added
2. customThe solvent was evaporated in vacuo and 2N hydrochloric acid
3. additionwas added to the residue
4. filtrationThe product was filtered
5. washwashed with water
6. customRecrystallization from isopropanol-water