Acetophenone → 1-Phenyl-3-(3-methoxy-4-hydroxy-5-trifluoromethylphenyl)prop-2-en-1-one

HRID 1974722Notes

Reaction equation

HRID 1974722 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([C:12]([F:15])([F:14])[F:13])[C:10]=1[OH:11])[CH:6]=O.[C:16]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)(=[O:18])[CH3:17]>>[C:19]1([C:16](=[O:18])[CH:17]=[CH:6][C:5]2[CH:8]=[C:9]([C:12]([F:15])([F:14])[F:13])[C:10]([OH:11])=[C:3]([O:2][CH3:1])[CH:4]=2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 7410AcetophenoneHCID 193891994-Hydroxy-3-methoxy-5-(trifluoromethyl)benzaldehyde

Product 1

HCID 540570871-Phenyl-3-(3-methoxy-4-hydroxy-5-trifluoromethylphenyl)prop-2-en-1-one

Procedure

The procedure described in Example 8 was repeated using 1.7 g of 3-methoxy-4-hydroxy-5-trifluoromethylbenzaldehyde and 1.0 g of acetophenone. Yield 1.1 g (45%), m.p. 166°-168° C.

Sources & evidence

ORD record
ord-9c49852b6d544954b0fafc66d3daac1a
Source dataset
uspto-grants-1994_02
Patent number
US05283352

Reaction notes

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