Acetophenone → 1-Phenyl-3-(3,4-dihydroxy-5-trifluoromethylphenyl)prop-2-en-1-one

HRID 1974728Notes

Reaction equation

HRID 1974728 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([C:11]([F:14])([F:13])[F:12])[C:9]=1[OH:10])[CH:5]=O.[C:15]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)(=[O:17])[CH3:16]>>[OH:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:16][C:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:17])[CH:7]=[C:8]([C:11]([F:14])([F:13])[F:12])[C:9]=1[OH:10]

Participants

3

Reactant 2

HCID 7410AcetophenoneHCID 193891883,4-Dihydroxy-5-(trifluoromethyl)benzaldehyde

Product 1

HCID 540139591-Phenyl-3-(3,4-dihydroxy-5-trifluoromethylphenyl)prop-2-en-1-one

Procedure

The procedure described in Example 8 was repeated using 2.06 g of 3,4-dihydroxy-5-trifluoromethylbenzaldehyde and 1.20 g of acetophenone. Yield 2.19 g (71%), m.p. 196°-210° C.

Sources & evidence

ORD record
ord-e89f4c5612574301ace95e2c17994f20
Source dataset
uspto-grants-1994_02
Patent number
US05283352

Reaction notes

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