HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3,4-Dihydroxy-5-(trifluoromethyl)benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Hydroxy-3-methoxy-5-(trifluoromethyl)benzaldehyde | HCID 19389199 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Boron tribromide | HCID 25134 | — |
| Product | 3,4-Dihydroxy-5-(trifluoromethyl)benzaldehyde | HCID 19389188 | — |
Reaction Steps
A solution containing 2.2 g of 4-hydroxy-3-methoxy-5-trifluoromethylbenzaldehyde in 65 ml of 1 molar BBr3 in dichloromethane was stirred for 2 h at room temperature. Hydrochloric acid was added and the organic phase was separated. The solvent was evaporated in vacuo. Yield 1.4 g (68%), m.p. 188°-192° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05283352 |
| Source dataset | uspto-grants-1994_02 |
| ORD ID | ord-fb5b819e0a4c4217bb12c7dbaf45d7b5 |
| Source note | uspto-grants-1994_02 |