Hydrochloric Acid → HCID 54383067, compound

Participants

Reaction Steps

To N-[3-[2-(4-fluorophenylthio)phenyl]prop-2-enyl]-O-tetrahydropyranyl hydroxylamine (1.76 g; 4.9 mmol) in 25 ml of methanol and cooled in an ice bath was added 2.5 ml of concentrated HCl dropwise. The reaction mixture was stirred at room temperature overnight and then concentrated to dryness. The mixture was partitioned between diethyl ether and saturated NaHCO3 and the aqueous layer extracted one more time with diethyl ether. The organics were combined, washed with water and brine and dried over K2CO3 to afford the subtitle compound.

Provenance & Evidence