反应详情

2-(Trifluoroacetamido)benzamide (73.0 g, 0.31 mole) was heated in ethylene glycol (150ml) in an oil bath with stirring. The amide dissolved at around 130° and product began to precipitate out at 150°. The temperature was held at 150° for a further 1 hour before cooling. The solid was filtered off washing well with cold water to give the product, 55.7 g (84%).

1. customto precipitate out at 150°
2. temperaturebefore cooling
3. filtrationThe solid was filtered off
4. washwashing well with cold water
5. customto give the product, 55.7 g (84%)