Sodium Hydroxide → HCID 14476366, compound

Participants

Reaction Conditions

Reaction Steps

A mixture containing 2.9 g of 3-bromo-2,2-dimethyl-4-hydroxy-6-trifluoroacetylchromane, prepared in the previous step, 25 ml of dioxane, 0.5 g of sodium hydroxide pellets and 5 ml of water is stirred at 20° C. for 20 hours. After concentration under vacuum at 40° C., the residue is treated 4 times with 100 ml of ethyl ether and the extracts are then dried and concentrated under vacuum to give 2 g of a yellow oil.

Provenance & Evidence