Benzyltrimethylammonium hydroxide → HCID 14476368, compound

Participants

Reaction Steps

A mixture containing 1.9 g of 2,2-dimethyl-3,4-epoxy-6-trifluoroacetylchromane (PREPARATION II), 1.4 g of 2-hydroxypyridine, 5 ml of dioxane and 0.2 ml of a methanolic solution containing 35% of benzyltrimethylammonium hydroxide is refluxed for 20 hours. The residue obtained after concentration under vacuum is taken up with 20 ml of water and the insoluble material is then filtered off and washed with water and boiling isopropyl ether. It is chromatographed on a column of 50 g of silica using a methylene chloride/ethyl acetate mixture (7/3) as the eluent. This gives 0.3 g of dry product.

Provenance & Evidence