Water → HCID 54733813, compound

Participants

Reaction Steps

3 g of 6-cyano-2,2-dimethyl-3,4-epoxychromane are refluxed for 20 hours with 1.8 g of 2,4-dihydroxypyridine in 30 ml of dioxane and 20 ml of dimethylformamide, in the presence of 0.6 ml of a methanolic solution containing 35% of benzyltrimethylammonium hydroxide. The solvents are evaporated off under vacuum and the residue is then crystallized by the addition of isopropyl ether. The crystals obtained are taken up with water, filtered off and then washed with acetone to give 850 mg of the expected product.

Provenance & Evidence