Water → HCID 135795212, compound

HRID 1974852Notes

Reaction equation

HRID 1974852 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH2:11][CH:12]2[CH2:17][O:16][P:15]([O:19][CH2:20][CH3:21])(=[O:18])[CH2:14][CH2:13]2)=[C:4](Cl)[N:3]=1.[OH2:23].[OH-:24].[Na+:25]>C(O)C>[NH:3]1[C:4](=[O:23])[C:5]2[N:6]=[CH:7][N:8]([CH2:11][CH:12]([CH2:17][OH:16])[CH2:13][CH2:14][P:15]([O:19][CH2:20][CH3:21])(=[O:24])[O-:18])[C:9]=2[N:10]=[C:2]1[NH2:1].[Na+:25]

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 19027587HCID 19027587, compound

Product 1

HCID 135795212HCID 135795212, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-Amino-6-chloro-9-[(2-ethoxy-2-oxo-1,2-oxaphosphorinan-5-yl)-methyl]purine (VSC 655) and its 7 isomer (100 mg, 0.29 mmol), dissolved in ethanol (4 ml), water (4 ml), and 2M aqeous sodium hydroxide (0.90 mmol) was kept at 37° C. for 18 h. The solution was neutralized by addition of weakly acidic Amberlite cation exchange resin, filtered, and evaporated to dryness to give 113 mg (quantitative yield) of a crude product.

Workup

  1. additionThe solution was neutralized by addition of weakly acidic Amberlite cation exchange resin
  2. filtrationfiltered
  3. customevaporated to dryness

Sources & evidence

ORD record
ord-9c0e89825aa94bbb8a3930a3ed88763c
Source dataset
uspto-grants-1994_02
Patent number
US05284837

Reaction notes

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