HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-ethylaminomethyl-3-hydroxypyrrolidine-1-carboxylate → 3-Ethylaminomethyl-3-hydroxypyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-ethylaminomethyl-3-hydroxypyrrolidine-1-carboxylate | HCID 14578449 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Ethylaminomethyl-3-hydroxypyrrolidine | HCID 14578450 | — |
Reaction Steps
7.7 g (35.6 mmol) of ethyl 3-ethylaminomethyl-3-hydroxypyrrolidine-1-carboxylate are heated under reflux overnight with 22 g of Ba(OH)2. 8H2O in 220 ml of water. The mixture is filtered off with suction from BaCO3 and concentrated. The residue is boiled five times using 100 ml of dioxane each time, and the dioxane solution is concentrated and distilled.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05284842 |
| Source dataset | uspto-grants-1994_02 |
| ORD ID | ord-982a95d78f1c427ab213de8067d2bf3b |
| Source note | uspto-grants-1994_02 |