HCID 19382170, compound → HCID 19382210, compound

HRID 1974860Notes

Reaction equation

HRID 1974860 reaction equation
[ClH:1].Cl.C([N:10]1[CH2:14][CH2:13][C:12]([OH:18])([CH2:15][NH:16][CH3:17])[CH2:11]1)C1C=CC=CC=1>CO.[Pd]>[ClH:1].[ClH:1].[OH:18][C:12]1([CH2:15][NH:16][CH3:17])[CH2:13][CH2:14][NH:10][CH2:11]1

Participants

4

Reactant 1

HCID 19382170HCID 19382170, compound

Product 1

HCID 19382210HCID 19382210, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

6.9 g (23.5 mmol) of 1-benzyl-3-hydroxy-3-methylaminomethylpyrrolidine dihydrochloride in 100 ml of methanol are hydrogenated on 2 g of palladium/active carbon (10%) at 80° C. and 100 bar. The catalyst is filtered off with suction, the solution is concentrated and the residue is triturated with butanol. The crystalline salt is filtered off with suction, washed with acetone and dried.

Workup

  1. filtrationThe catalyst is filtered off with suction
  2. concentrationthe solution is concentrated
  3. customthe residue is triturated with butanol
  4. filtrationThe crystalline salt is filtered off with suction
  5. washwashed with acetone
  6. customdried

Sources & evidence

ORD record
ord-188950bb3334453e9cd16531e1cbbd66
Source dataset
uspto-grants-1994_02
Patent number
US05284842

Reaction notes

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