HCID 14578461, compound → HCID 14578465, compound

HRID 1974865Notes

Reaction equation

HRID 1974865 reaction equation
[OH:1][C:2]1([CH2:12][NH:13][CH3:14])[CH2:7][CH2:6][CH2:5][N:4](C(OC)=O)[CH2:3]1>O>[OH:1][C:2]1([CH2:12][NH:13][CH3:14])[CH2:7][CH2:6][CH2:5][NH:4][CH2:3]1

Participants

3

Reactant 1

HCID 14578461HCID 14578461, compound

Product 1

HCID 14578465HCID 14578465, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

8.7 g (43 mmol) of methyl 3-hydroxy-3-methylaminomethylpiperidine-1-carboxylate are heated overnight under reflux with 24 g of Ba(OH)2. 8H2O in 240 ml of water. The product is filtered off from BaCO3 with suction and concentrated. The residue is boiled five times using 100 ml of dioxane each time, and the dioxane solution is concentrated and distilled.

Workup

  1. filtrationThe product is filtered off from BaCO3 with suction
  2. concentrationconcentrated
  3. concentrationthe dioxane solution is concentrated
  4. distillationdistilled

Sources & evidence

ORD record
ord-2b021c1949b64a548732246beaf93647
Source dataset
uspto-grants-1994_02
Patent number
US05284842

Reaction notes

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