HCID 14578462, compound → HCID 14578464, compound

HRID 1974867Notes

Reaction equation

HRID 1974867 reaction equation
[CH2:1]([NH:3][CH2:4][C:5]1([OH:15])[CH2:10][CH2:9][CH2:8][N:7](C(OC)=O)[CH2:6]1)[CH3:2]>O>[CH2:1]([NH:3][CH2:4][C:5]1([OH:15])[CH2:10][CH2:9][CH2:8][NH:7][CH2:6]1)[CH3:2]

Participants

3

Reactant 1

HCID 14578462HCID 14578462, compound

Product 1

HCID 14578464HCID 14578464, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

10 g (46.2 mmol) of methyl 3-ethylaminomethyl-3-hydroxypiperidine-1-carboxylate are heated under reflux overnight with 28.5 g of Ba(OH)2. 8H2O in 280 ml of water. The product is filtered off from BaCO3 with suction and concentrated. The residue is boiled five times using 120 ml of dioxane each time, and the dioxane solution is concentrated and distilled.

Workup

  1. filtrationThe product is filtered off from BaCO3 with suction
  2. concentrationconcentrated
  3. concentrationthe dioxane solution is concentrated
  4. distillationdistilled

Sources & evidence

ORD record
ord-d21f7f4396804e4b992bc88ab4db14b4
Source dataset
uspto-grants-1994_02
Patent number
US05284842

Reaction notes

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