HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → Ethyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Ethyl 1-oxa-6-azaspiro[2,5]octane-6-carboxylate | HCID 13672926 | — |
| Product | Ethyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate | HCID 14049029 | — |
Reaction Steps
13.4 g (72.3 mmol) of ethyl 6-aza-1-oxaspiro[2,5]octane-6-carboxylate (European Patent Application 189,370) are added dropwise to 60 ml of ammonia solution (25%) and the mixture is stirred overnight at room temperature. It is then concentrated and distilled.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05284842 |
| Source dataset | uspto-grants-1994_02 |
| ORD ID | ord-3891d18672ca463abe242fc38b85d903 |
| Source note | uspto-grants-1994_02 |