HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1-Dimethylethyl N-[[3-hydroxy-1-(phenylmethyl)-3-pyrrolidinyl]methyl]carbamate → 3-(Boc-aMinoMethyl)-3-hydroxypyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1-Dimethylethyl N-[[3-hydroxy-1-(phenylmethyl)-3-pyrrolidinyl]methyl]carbamate | HCID 54489372 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Palladium | HCID 23938 | — |
| Product | 3-(Boc-aMinoMethyl)-3-hydroxypyrrolidine | HCID 53716102 | — |
Reaction Steps
18.7 g (61 mmol) of 1-benzyl-3-tert.-butoxycarbonylaminomethyl-3-hydroxypyrrolidine are dissolved in 120 ml of methanol and hydrogenated on 3 g of 5% strength Pd/active carbon at 90° C. and 100 bar. The catalyst is filtered off, the filtrate is concentrated and the residue is recrystallized from ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05284842 |
| Source dataset | uspto-grants-1994_02 |
| ORD ID | ord-5d21f7c4e10b45aea8b2dabea91dc9de |
| Source note | uspto-grants-1994_02 |