HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 1-Benzyl-3-hydroxymethyl-3-methoxypyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | 1-Benzyl-3-methoxypyrrolidine-3-carboxylic acid methylester | HCID 53715308 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 1-Benzyl-3-hydroxymethyl-3-methoxypyrrolidine | HCID 19382171 | — |
Reaction Steps
6.5 g Lithium aluminum hydride are suspended in 250 ml of dry diethylether. 42 g (0.16 mol) 1-benzyl-3-methoxypyrrolidine-3-carboxylic acidmethylester are added dropwise. The mixture is stirred for 2 hours under reflux. Thereafter 6.5 ml of water, 6.5 ml 15% proof KOH and 6.5 ml of water are added, the inorganic salts are removed by filtration and washed twice with tetrahydrofurane. The organic solvents are removed from the filtrate in vacuo and the resedue is destilled.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05284842 |
| Source dataset | uspto-grants-1994_02 |
| ORD ID | ord-08c9b8e9854645878982e3dc4f8082c1 |
| Source note | uspto-grants-1994_02 |