1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid → HCID 14578487, compound

HRID 1974888Notes

Reaction equation

HRID 1974888 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:15])=[C:11](F)[CH:12]=3)[C:7](=[O:16])[C:6]([C:17]([OH:19])=[O:18])=[CH:5]2)[CH2:3][CH2:2]1.[CH2:20]([NH:22][CH2:23][C:24]1([OH:30])[CH2:29][CH2:28][CH2:27][NH:26][CH2:25]1)[CH3:21]>>[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:15])=[C:11]([N:26]4[CH2:27][CH2:28][CH2:29][C:24]([CH2:23][NH:22][CH2:20][CH3:21])([OH:30])[CH2:25]4)[CH:12]=3)[C:7](=[O:16])[C:6]([C:17]([OH:19])=[O:18])=[CH:5]2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 52104221-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acidHCID 14578464HCID 14578464, compound

Product 1

HCID 14578487HCID 14578487, compound

Procedure

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid is reacted analogously to Example 1 with 3-ethylaminomethyl-3-hydroxypiperidine to give 1-cyclopropyl-7-(3-ethylaminomethyl-3-hydroxy-1-piperidinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid of melting point 199°-203° C. (with decomposition).

Sources & evidence

ORD record
ord-f5a4298340e845c8b6057a1cdb75b6ef
Source dataset
uspto-grants-1994_02
Patent number
US05284842

Reaction notes

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