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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1974889Generated: October 31, 2026

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid → HCID 14578478, compound

https://huagongshe.com/reaction/1974889

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acidHCID 5210422—
Reactant1,4-Dioxa-7-azaspiro(4.4)nonaneHCID 15165039—
ProductHCID 14578478HCID 14578478—

Reaction Steps

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid is reacted analogously to Example 11 with 1,4-dioxa-7-azaspiro[4.4]nonane to give 1-cyclopropyl-7-(1,4-dioxa-7-azaspiro[4.4]non-7-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid of melting point 229°-230°.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05284842
Source datasetuspto-grants-1994_02
ORD IDord-19e876fd46fc4845a7db573ec42d2826
Source noteuspto-grants-1994_02