1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid → HCID 19382177, compound

HRID 1974891Notes

Reaction equation

HRID 1974891 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:15])=[C:11](F)[CH:12]=3)[C:7](=[O:16])[C:6]([C:17]([OH:19])=[O:18])=[CH:5]2)[CH2:3][CH2:2]1.[N:20]1([CH2:25][C:26]2([OH:31])[CH2:30][CH2:29][NH:28][CH2:27]2)[CH2:24][CH2:23][CH2:22][CH2:21]1>>[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:15])=[C:11]([N:28]4[CH2:29][CH2:30][C:26]([CH2:25][N:20]5[CH2:24][CH2:23][CH2:22][CH2:21]5)([OH:31])[CH2:27]4)[CH:12]=3)[C:7](=[O:16])[C:6]([C:17]([OH:19])=[O:18])=[CH:5]2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 52104221-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acidHCID 19382151HCID 19382151, compound

Product 1

HCID 19382177HCID 19382177, compound

Procedure

1-Cyclopropyl-6,7-diflouro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid and 3-(1-pyrrolidinylmethyl)-3-hydroxy-pyrrolidine are reacted according to example 1, yielding 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7[3-(1-pyrrolidinylmethyl)-3-hydroxy-1-pyrrolidinyl]-3-quinoline carboxylic acid, melting point 229°-234° C. (decomposition).

Sources & evidence

ORD record
ord-b64e0277472643d9b6e899ae53c4a676
Source dataset
uspto-grants-1994_02
Patent number
US05284842

Reaction notes

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