HCID 19100774, compound → HCID 19100699, compound

Participants

Reaction Steps

A suspension of ethyl 2-ethoxalylamino-3-nitro-4-propylthiophene-5-carboxylate (4.2 g, 11.7 mmol) and zinc dust (3.83 g, 58.6 mmol) in 57 ml of 80% aqueous acetic acid was stirred under a nitrogen atmosphere in a water bath for 1 hour. The reaction mixture was decanted from the residual zinc and poured into ice water. The precipitate was filtered off, washed with water and dried. Recrystallization from ethanol (300 ml) afforded 1.67 g (62%) of the title compound. M.p.305°-307° C. 1H-NMR (DMSO-D6,δ): 0.93 (t, 3H), 1.28 (t, 3H), 1.49 (hex, 2H), 2.96 (t, 3H), 4.26 (q, 2H), 12.06 (s, 1H), 12.54 (s, 1H).

Provenance & Evidence