HCID 23186993, compound → 7-Methyl-2,3-dioxo-1,2,3,4-tetrahydrothieno[2,3-b]pyrazine-6-carboxylic acid

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Reaction Steps

6-Ethoxycarbonyl-7-methylthieno[2,3-b]pyrazine-2,3-(1H,4H)-dione (60 mg, 0.236 mmol) was warmed in 1 M NaOH (0.944 ml) at 50° C. under stirring for 8 hours. The mixture was filtrated and acidified with 2 M HCl (1.0 ml) under cooling in an ice bath. The precipitate was filtered off, washed with water and dried to afford 29 mg (54%) of the title compound. M.p. 289°-294° C. 1H-NMR (DMSO-D6, δ): 2.45 (s, 3H), 11.96 (s, 1H), 12.45 (s, 1H), 12.96 (s, 1H).

Provenance & Evidence