Diethyl Oxalate → HCID 19100723, compound

Participants

Reaction Steps

A mixture of di-t-butyl 4-cyclopropylthiophene-2,3-dicarbamate (1.66 g, 4.7 mmol), diethyl oxalate (20 ml, 146 mmol) and glacial acetic acid (20 ml) was refluxed for 12 h. The mixture was concentrated in vacuo and the residue recrystallized from glacial acetic acid to afford 460 mg (72%) of the title compound. M.p.>250° C. 1H-NMR (DMSO-d6, δ): 0.6 (m, 2H), 0.85 (m, 2H), 2.0 (m, 1H), 6.55 (s, 1H), 12.0 (s, 1H), 12.2 (s, 1H).

Provenance & Evidence