tert-Butanol → HCID 19100744, compound

Participants

Reaction Steps

A mixture of 2-t-butoxycarbonylamino-4-cyclohexylthiophene-3-carboxylate (7.5 g, 23 mmol) in 2-methyl-2-propanol (400 ml), triethylamine (2.33 g, 23 mmol) and diphenylphosphoryl azide was heated at reflux for 16 h. The reaction mixture was concentrated in vacuo and the residue submitted to flash chromatography using silica gel 60 eluting with toluene to give 400 mg (4%) of di-t-butyl 4-cyclohexylthiophene-2,3-dicarbamate as an oil.

Provenance & Evidence