Ethanol → HCID 19100693, compound

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Reaction Steps

A mixture of ethyl bis(t-butoxycarbonyl)amino-4-phenylthiophene-3-carboxylate (4.37 g, 9.76 mmol), 40 ml of ethanol, 20 ml of water and 2.19 g of potassium hydroxide was heated at reflux for 3 h. The mixture was cooled and acidified with 2.9 ml of--acetic acid. The precipitate was isolated to give 2.70 g (87%) of 2-t-butoxycarbonylamino4-phenylthiophene-3-carboxylic acid. M.p. 183° C. (dec.). 1H-NMR (DMSO-D6, δ): 1.5 (s, 9H), 6.7 (s, 1H), 7.3 (m, 5H), 11.5 (br.s, 1H).

Provenance & Evidence