Sulfuryl chloride → HCID 19100800, compound

HRID 1975000Notes

Reaction equation

HRID 1975000 reaction equation
[C:1]([C:3]1[C:11]2[NH:10][C:9](=[O:12])[C:8](=[O:13])[NH:7][C:6]=2[S:5][CH:4]=1)#[N:2].S(Cl)([Cl:17])(=O)=O>C(O)(=O)C>[Cl:17][C:4]1[S:5][C:6]2[NH:7][C:8](=[O:13])[C:9](=[O:12])[NH:10][C:11]=2[C:3]=1[C:1]#[N:2]

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 19100688HCID 19100688, compound

Product 1

HCID 19100800HCID 19100800, compoundYield 37.3%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Chlorination of 7-cyanothieno(2,3-b]pyrazine-2,3(1H,4H)-dione (386 mg, 2 mmol) in acetic acid (50 ml) with sulfuryl chloride (250 pl, 3.1 mmol) was performed following the procedure outlined in example 5 (Method G) to give 170 mg (37%) of the title compound. M.P.>250° C. 1H-NMR (DMSO-D6, δ): 12.25 (br.s, 1H), 12.8 (br.s, 1H).

Sources & evidence

ORD record
ord-ab11cd50bf8b4817aefc5133fe76e532
Source dataset
uspto-grants-1994_02
Patent number
US05284847

Reaction notes

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