N-Benzylglycine ethyl ester → 2-(Benzylamino)acetic acid

Participants

Reaction Steps

225.8 g (1. 17 mol) of ethyl N-benzylglycinate (J. Am. Chem. Soc. 72, 1238 (1950)) are refluxed overnight in 600 ml of water. The product which has crystallised out is filtered off with suction and the filtrate is extracted once using tert.-butyl methyl ether. The aqueous phase is concentrated and the crystals obtained together with the product which has been faltered of fare dried in a desiccator over phosphorus pentoxide.

Provenance & Evidence