Octahydro-6-methyl-1-(phenylmethyl)pyrrolo[3,4-b]pyrrole → HCID 22924398, compound

HRID 1975021Notes

Reaction equation

HRID 1975021 reaction equation
C([N:8]1[CH2:15][CH2:14][CH:13]2[CH:9]1[CH:10]([CH3:16])[NH:11][CH2:12]2)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:16][CH:10]1[CH:9]2[CH:13]([CH2:14][CH2:15][NH:8]2)[CH2:12][NH:11]1

Participants

4

Reactant 1

HCID 19100934Octahydro-6-methyl-1-(phenylmethyl)pyrrolo[3,4-b]pyrrole

Product 1

HCID 22924398HCID 22924398, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

7.8 g (36 mmol) of 2-benzyl-8-methyl-2,7-diazabicyclo[3.3.0]octane in 200 ml of ethanol are hydrogenated on 2 g of palladium/active carbon (10% Pd) at 100° C. and 100 bar. The catalyst is filtered off with suction, the filtrate is concentrated, and the residue is distilled. The distillate crystallises.

Workup

  1. filtrationThe catalyst is filtered off with suction
  2. concentrationthe filtrate is concentrated
  3. distillationthe residue is distilled

Sources & evidence

ORD record
ord-75fef74c17804d939a2981fed0931226
Source dataset
uspto-grants-1994_02
Patent number
US05284855

Reaction notes

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