HCID 19100946, compound → HCID 22924376, compound

HRID 1975024Notes

Reaction equation

HRID 1975024 reaction equation
C([N:8]1[CH2:15][CH2:14][CH:13]2[CH:9]1[CH:10]([CH3:17])[N:11]([CH3:16])[CH2:12]2)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:16][N:11]1[CH:10]([CH3:17])[CH:9]2[CH:13]([CH2:14][CH2:15][NH:8]2)[CH2:12]1

Participants

4

Reactant 1

HCID 19100946HCID 19100946, compound

Product 1

HCID 22924376HCID 22924376, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

10.8 g (46.9 mmol) of 2-benzyl-7,8-dimethyl-2,7-diazabicyclo[3.3.0]octane in 200 ml of ethanol hydrogenated on 2.5 g of palladium/active carbon at 100° C. and 100 bar. The catalyst is filtered off with suction, the filtrate is concentrated, and the residue is distilled.

Workup

  1. filtrationThe catalyst is filtered off with suction
  2. concentrationthe filtrate is concentrated
  3. distillationthe residue is distilled

Sources & evidence

ORD record
ord-4c2bb6f1ce364bcbab6a87c8e8bd8914
Source dataset
uspto-grants-1994_02
Patent number
US05284855

Reaction notes

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