HCID 19100944, compound → HCID 22924404, compound

HRID 1975033Notes

Reaction equation

HRID 1975033 reaction equation
C([N:8]1[CH2:15][CH2:14][C:13]2([CH3:16])[CH:9]1[CH2:10][N:11]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:12]2)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:16][C:13]12[CH2:12][N:11]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:10][CH:9]1[NH:8][CH2:15][CH2:14]2

Participants

4

Reactant 1

HCID 19100944HCID 19100944, compound

Product 1

HCID 22924404HCID 22924404, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

2.6 g (10.3 mmol) of tert.-butyl 2-benzyl-5-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate in 50 ml of ethanol are hydrogenated on 0.5 g of palladium/active carbon (10% Pd) at 130° C. and 100 bar. The catalyst is filtered off with suction, and the liquid phase is concentrated and distilled.

Workup

  1. filtrationThe catalyst is filtered off with suction
  2. concentrationthe liquid phase is concentrated
  3. distillationdistilled

Sources & evidence

ORD record
ord-f7d3e32a1bbe4400bb6744d56dd86ed8
Source dataset
uspto-grants-1994_02
Patent number
US05284855

Reaction notes

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