Nicotinamide → HCID 14986521, compound

Participants

Reaction Steps

The title compound was prepared as described for Example 3 starting with 6-bromo-5,6-dihydro-7-hydroxy-5,5-dimethyl-7H -thieno[3,2-b]pyran (4.0 g, 15.2 mmol) and nicotinamide (3.7 g, 30.4 mmol) to give 1.1 g (24%): m.p. 248°-49° C.; IR (KBr): 3329, 3312,1648, 1594, 1569 cm-1 ; MS: m/z 305 (MH+); 1 1H NMR (CDCl3) 6 9.02 (s, 1H), 8.79 (d, J=5,6 Hz, 1H), 8.14 (d, J=5,6 Hz, 1H), 7.44 (m, 1H), 7.18 (d, J=5.4 Hz, 1H), 6.64 (d, J=5.4 Hz, 1H), 6.55 (d, J=5,6, 1H), 5.20 (m, 1H), 4.46 (brs, 1H), 3.81 (d, J=9.4 Hz, 1H), 1.50 (s, 3H), 1.36 (s, 3H).

Provenance & Evidence