N-bromobutanimide → HCID 67805967, compound

Participants

Reaction Steps

N-Bromosuccinimide (15.0 g, 84.3 mmol) was added to a solution of 5,6-dihydro-5,5-dimethyl-7H-thieno-[3,4-b]pyran-7-one (15.0 g, 82.6 mmol) in dichloromethane (300 mL) at 0° C., and the resultant solution was stirred for 2 h at 0° C. The solution was washed with water and dried over magnesium sulfate. The solvent was evaporated in vacuo to give the product as a dark grey solid, 15.1 g (70%), mp 63°-72° C.; IR(neat): 1694, 1558 and 1438 cm-1 : MS: m/z 261 (MH+); 1H NMR(CDCl3): δ 1.47 (s, 6H), 2.63 (s, 2H),7.99 (s, 1H).

Provenance & Evidence